If you are lacking in motivation to exercisethis fall, some research led by a University of Florida researcher may inspire you to jump-startyour fitness regimen.

According to the new study, while exercising,a hormone is released that not only helps the body shed fat, but also prevents it fromforming.

A professor of cell biology and a team atHarvard Medical School discovered the hormone dubbed "irisin" in 2012.

They isolated the natural hormone from musclecells that trigger some of the health-promoting properties of exercise, which, they say, couldbe developed into novel treatments for diabetes, obesity, and cancer.

In the previous study, the Harvard-affiliatedteam also found that as irisin levels rise through exercise, the hormone switches ongenes that convert white fat into brown fat – the "good" fat.

This conversion is beneficial, as brown fatburns off more excess calories than exercise alone.


Li-Jun Yang, a professor of hematopathologyin the Department of Pathology, Immunology and Laboratory Medicine at the Universityof Florida College of Medicine, directed the new research.

The researchers note that they believe theresearch to be the first of its kind to explore irisin's effects on human fat tissue and fatcells.

According to the researchers, irisin hormone- which surges when the heart and other muscles are exerted – may also inhibit the formationof fatty tissue.

The study findings, published in the AmericanJournal of Physiology – Endocrinology and Metabolism, confirms previous conclusionsthat irisin may be a promising target to support people with obesity and type 2 diabetes.

Irisin works via a mechanism that boosts theactivity of genes and a protein that are crucial to turning white fat cells into brown fatcells.

The researchers also found irisin to havea role in burning fat by significantly increasing the amount of energy used by brown fat cells.


Yang and team conducted the research bycollecting fat cells donated by 28 participants who had undergone breast reduction surgery.

Scientists exposed the fat samples to irisin,and as a result, saw an almost fivefold increase in cells that contain the UCP1 protein – aprotein crucial to fat burning.

"We used human fat tissue cultures to provethat irisin has a positive effect by turning white fat into brown fat and that it increasesthe body's fat-burning ability," says Dr.


Fat cell formation significantly suppressedby irisin hormone Among the analyzed fat tissue samples, Dr.

Yang and collaborators found that irisin suppresses fat cell formation by reducing the numberof mature fat cells by 20-60 percent, when compared with the control group.

This finding indicates that the irisin hormonereduces fat storage in the body by hindering the process that turns undifferentiated stemcells into fat cells, while also promoting the stem cells' differentiation into bone-formingcells, the researchers say.

More than two thirds of U.

S adults are consideredto be overweight or obese.

While there is no single approach to preventor treat overweight and obesity, exercise in combination with behavioral treatment anddiet can aid weight loss.

The knowledge that the body produces smallquantities of fat-fighting irisin emphasizes the importance of regular exercise.


Yang says that while the beneficial effectsof irisin could potentially be developed into therapies in the future, the viability ofan irisin-based treatment is uncertain and would not happen imminently.

"Instead of waiting for a miracle drug, youcan help yourself by changing your lifestyle.

Exercise produces more irisin, which has manybeneficial effects including fat reduction, stronger bones, and better cardiovascularhealth.

" Dr.

Li-Jun Yang Irisin's role in regulating fat cells shedslight on the way physical activity helps people stay slender, says Dr.


"Irisin can do a lot of things.

This is another piece of evidence about themechanisms that prevent fat buildup and promote the development of strong bones when you exercise,"she adds.

This study adds to increasing informationregarding irisin's health benefits.

Previous studies by Dr.

Yang's group foundthat irisin improves heart function by boosting calcium levels that are critical for heartcontractions.

They also showed that the hormone reducedarterial plaque buildup in mouse models by preventing inflammatory cells from accumulating,thus reducing atherosclerosis.

Future work for the team will focus on irisin'seffect on abdominal fat, which is associated with insulin resistance and high lipid levels: Please Subscribe To Our Channel And Also ShareIt With Your Friends Thank You:.

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